This is the first dietary intervention feeding study, to the best of our knowledge, to report 100% remission of pre-diabetes with a HP diet and significant improvement in metabolic parameters and anti-inflammatory effects compared with a HC diet at 6 months.
As the participants were obese and might be at risk for diabetes mellitus and coronary heart disease, it was prudent to ensure the participants follow a healthy diet that could minimize their health risks. For example, dietary fat sources focused on monounsaturated and polyunsaturated fats, that is, plant oils, semiliquid margarine, nuts;31–33 dietary CHO sources emphasized whole grains, fruits, vegetables and legumes; and dietary protein sources included lean meats, fish, chicken, eggs and non-fat dairy foods, that is, fat-free milk and low-fat cheese. The dietary principles are consistent with the guidelines of the Institute of Medicine32 and American Diabetes Association.34
Study participants either followed a HP or HC diet for 6 months, based on initial randomization using a randomization table. Calorie maintenance needs were determined on an individual basis using the RMR. After maintenance, caloric needs were established for each individual; 500 kcals/day were subtracted from the determined caloric needs to promote a 1–2 lbs weekly weight loss. On average, an 1800 kcal/day diet for a 100 kg individual was used to achieve adequate weight loss.
A one-time calorie reduction of 200 kcal was made if a subject reached a plateau and did not lose weight for two consecutive weeks during the 6 months. No subject was on <1200 kcal/day.
Käyttäjiä lukemassa tätä aluetta: Ei rekisteröityneitä käyttäjiä ja 6 vierailijaa